Major Histocompatibility Complex (MHC) is a critical component of the immune system, found in most vertebrates. It consists of a group of genes responsible for encoding cell surface proteins that present antigens to immune cells, primarily T cells. MHC molecules play a pivotal role in self-recognition and distinguishing foreign substances from the body's own tissues. There are two major classes of MHC molecules, MHC class I (present on most nucleated cells) and MHC class II (mainly on antigen-presenting cells), which interact with CD8+ and CD4+ T cells, respectively. This interaction is crucial for initiating immune responses, including cytotoxicity, antibody production, and immune memory formation.
Notes Credit : Bhumika Puri (B.Tech Biotechnology) 4th Year
